A double-blind placebo-controlled study involving 168 participants aged 19-50 years old was conducted over 8 weeks to determine the effect of CQR-300 in participants with a BMI>30. 

Key Findings:

• Supports reductions in body weight, body fat and cholesterol*
• Supports appetite control through an increase in serotonin levels*
• Has antioxidant properties to counter oxidative stress*

Source: The effect of cissus quadrangularis (CQR-300) and a cissus formulation (CORE) on obesity and obesity-induced oxidative stress

A randomized, double-blind, placebo-controlled pilot trial involving 67 subjects aged 25-60 years old, was conducted over 8 weeks to confirm the efficacy of CQR-300 in reducing body fat.

Key Findings:

• Supports decreases in body fat measured by DEXA* 
• Supports healthy adiponectin levels, a hormone that regulates fat metabolism* 
• Improves cholesterol and triglyceride levels* 

Source: The Use of a Stem and Leaf Aqueous Extract of Cissus Quadrangularis (CQR-300) to Reduce Body Fat and Other Components of Metabolic Syndroms in Overweight Participants

A randomized, double-blind, placebo-controlled study involving 61 participants aged 19-55 years old, was conducted over 8 weeks to test the efficacy of CQR-300 in improving metabolic parameters in participants with a BMI >28.

Key Findings:

• Supports improved waist and hip circumference*
• Supports healthy blood pressure and blood sugar levels*
• Supports increases in HDL (good) cholesterol*

Source: The use of cissus quadrangularis (CQR-300) in the management of components of metabolic syndrome in overweight and obese participants

A randomized double-blind placebo-controlled involving 72 participants aged 21-44 years old, was conducted for 10 weeks to evaluate the effects of combining CQR-300 with IGOB131 on weight loss.

Key Findings:

• Supports up to a 20% reduction in body fat*
• Supports up to 31% decrease in blood glucose*
• Supports up to a 44% decrease in total cholesterol*

Source: The use of a cissus quadrangularis/irvingia gabonensis combination in the management of weight loss: double-blind, placebo-controlled study

A randomized, double-blind, placebo-controlled study involving 123 participants aged 19-50 years old, was conducted for 8 weeks to investigate the use of CQR-300 in the management of certain metabolic factors.

Key Findings:

• Supports reductions in body fat % and waist circumference*
• Supports decreases in cholesterol and blood sugar levels*
• Supports reductions in C-reactive protein (inflammatory marker)* 

Source: The Use of Cissus Quadrangularis Formulation in the Management of Weight Loss and Metabolic Syndrome

A randomized, placebo controlled, double-blind study involving 32 participants was conducted over 20 weeks to investigate the efficacy of IGOB131’s active compound on body fat ratio and triglyceride levels in healthy adults. 

Key Findings: 

• Supports visceral and subcutaneous fat loss*
• Supports body weight and body fat ratio reductions*
• Supports reduced triglyceride levels*

Source: Effect of Ellagic Acid on Body Fat and Triglyceride Reduction in Healthy Overweight Volunteers: a Randomized, Double-blind, Placebo-controlled Parallel Group Study

A randomized, double-blind, placebo controlled study involving 102 participants was conducted over 10 weeks to evaluate the effects of IGOB131 on body weight and associated metabolic parameters. 

Key Findings: 

• Supports improvements in body weight, body fat, and waist circumference*
• Supports improvements in cholesterol and blood sugar levels* 
• Supports healthy leptin levels (a hormone that regulates satiety)*

Source: IGOB131, a Novel Seed Extract of the West African Plant Irvingia gabonensis, Significantly Reduces Body Weight and Improves Metabolic Parameters in Overweight Humans in a Randomized, Double-blind, Placebo-controlled Investigation.

A randomized, double-blind, placebo-controlled study involving 40 participants was conducted over 4 weeks to evaluate the efficacy of IGOB131 seeds in the management of metabolic factors. 

Key Findings: 

• Supports improved waist and hip circumference* 
• Supports healthy blood pressure levels*
• Supports a decrease in cholesterol*

Source: The Effect of Irvingia Gabonensis seeds on Body Weight and Blood Lipids of Obese Subjects in Cameroon

A randomized, double-blind, placebo-controlled study involving 48 participants was conducted over 8 weeks to investigate the effects of  IGOB131 in healthy participants. 

Key Findings: 

• Supports a reduction in body weight* 
• Supports a reduction in BMI*
• Supports a decrease in cholesterol and triglycerides*

Source: The Effect of Extracts of Irvingia gabonensis (IGOB131) and Dichrostachys glomerata (Dyglomera™) on Body Weight and Lipid Parameters of Healthy Overweight Participants

A randomized, double-blind placebo-controlled study involving 225 participants aged 18-65 years old  was conducted over 6 months to investigate the effects of Bifidobacterium animalis ssp. lactis 420 (B420) on body fat mass and other parameters.

Key Findings: 

• Supports a decrease in trunk fat mass*
• Supports curbed cravings and a regulated appetite*
• Reduces zonulin levels (marker of disrupted gut barrier function)*

Source: Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults—Randomized Controlled Trial

A randomized, double-blind, placebo-controlled study involving 134 participants aged 18-65 years old was conducted over 6 months to test if Bifidobacterium animalis ssp. lactis 420 (B420) is associated with changes in gut microbiota.

Key Findings: 

• Supports increases in Akkermansia (associated with improved metabolic health)*
• Supports a healthy gut microbiome (increases the ratio of "good to bad gut bacteria")*
• Supports gut barrier function*

Source: Probiotic or Synbiotic Alters the Gut Microbiota and Metabolism in a Randomised Controlled Trial of Weight Management in Overweight Adults

An analysis of the in vitro, pre-clinical, and clinical studies that have investigated the effects of Bifidobacterium animalis ssp. lactis 420 (B420) was conducted to determine its effects on gut microbiota and metabolic health. 

Key Findings:

• Supports improved gut barrier function* 
• Supports an improvement in waist to hip ratio*
• Supports improvements in gut dysbiosis*

Source: Bifidobacterium animalis subsp. lactis 420 for Metabolic Health: Review of the Research

A randomized, single-blind, placebo-controlled study involving 19 healthy male participants was conducted to examine the effects of grains of paradise on whole-body energy expenditure and brown adipose tissue (BAT) activity. 

Key Findings:

• Supports up to a 5x increase in calories burned over 2 hours*
• Supports increases in metabolic rate within 30 minutes of administration*
• Supports elevated metabolic rate for several hours over baseline*

Source: Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men

A randomized, single-blind, placebo-controlled, study involving 19 healthy female participants was conducted to examine the effect of daily ingestion of grains of paradise on whole-body energy expenditure and body fat. 

Key Findings:

• Supports decreases in visceral fat*
• Supports improved body composition* 
• Up to 97 more calories burned per day*

Source: Daily Ingestion of Grains of Paradise (Aframomum melegueta) Extract Increases Whole-Body Energy Expenditure and Decreases Visceral Fat in Humans

A randomized, single-blind, placebo-controlled study involving healthy male volunteers was conducted over 5 weeks to investigate if grains of paradise might revive brown adipose tissue (BAT) in individuals who have lost active BAT.

Key Findings: 

• Supports decreases in body fat %*
• Can elevate adaptive thermogenesis*
• Supports reactivation of brown adipose tissue (BAT)*

Source: Prolonged Treatment with Grains of Paradise (Aframomum melegueta) Extract Recruits Adaptive Thermogenesis and Reduces Body Fat